Gene Changes in Unexplained Pregnancy Loss
Study Summary
The purpose of this study is to learn more about the possible cause of miscarriage. Even with thorough evaluation and testing, the reasons for recurrent pregnancy loss can only be determined in about 60% of cases. By performing a more powerful test on the genetic material (inherited substances responsible for our unique characteristics) from miscarriage tissue, we expect to find changes in some samples that are not detected by the testing routinely done on this tissue. We also expect that studying changes in miscarriage tissue found by this newer method and comparing them to changes that may be found in the couples’ genetic material, will lead to a greater understanding of why some pregnancies do not progress.
Couples evaluated by Dr. Stephenson at the University of Chicago Recurrent Pregnancy Loss Program for a history of pregnancy loss will be asked to participate if chromosome testing of their miscarriage tissue reveals a normal result. The chromosomes will be retested using a new technology. The couple will be asked to donate blood for similar testing, to determine whether the genetic changes in miscarriage are inherited.
The benefits of participating in this study include contributing to medical research designed to answer some very important questions about inherited factors and recurrent pregnancy loss.
Participation Details
Inclusion criteria for the study include:
- At least two miscarriages of less than 20 weeks with the same partner
- At least one miscarriage with normal chromosome results